Naproxen is used to relieve pain from various conditions such as headaches, muscle aches, dental pain, and menstrual cramps. It also helps reduce pain, swelling, and joint stiffness caused by arthritis and gout attacks. Naproxen is classified as a nonsteroidal anti-inflammatory drug (NSAID). There are two types of Naproxen: regular Naproxen and Naproxen sodium. Prolonged or high-dose use of Naproxen may increase the risk of heart attack or stroke. Do not use Naproxen if you have a history of allergic reactions to aspirin or other NSAIDs.

Dosage Information

- Regular oral tablets: Available in doses of 220 mg (available over the counter), 250 mg, 275 mg, 375 mg, 500 mg, 550 mg.
- Delayed-release tablets: Available in doses of 375 mg and 500 mg.
- Slow-release tablets: Available in doses of 375 mg, 500 mg, and 750 mg.
- Capsules: Available in a dose of 220 mg.
- Oral suspension: 25 mg per milliliter.

The appropriate dose depends on the condition and severity and should be prescribed by a doctor. Generally, the maximum daily dose of Naproxen on the first day should not exceed 1250 mg and 1000 mg on subsequent days. Delayed-release tablets are not recommended for acute pain relief.

Uses

Naproxen is used to treat pain, arthritis, menstrual cramps, acute gout, and migraines. It is also used to manage cancer-related pain in children over two years old.

Drug Interactions

This medication may interact with other drugs such as Ibuprofen, Ketorolac, Methotrexate, and others. It is important to consult a doctor if you are taking other medications simultaneously.

Side Effects

Common side effects include abdominal pain, constipation, dizziness, drowsiness, headache, heartburn, shortness of breath, nausea, and edema (fluid accumulation in body tissues). Less common side effects may include gastrointestinal bleeding, ulcers, diarrhea, and hearing disorders.

Precautions

NSAIDs like Naproxen may increase the risk of cardiovascular issues such as heart attack and stroke (learn more). People with cardiovascular diseases are at greater risk.

This medication may cause problems such as bleeding and ulcers in the stomach or intestines, which can occur at any time without warning signs.

Contraindications

The use of Naproxen may lead to gastrointestinal bleeding or ulcers, which can occur at any time without warning signs.

Warnings

• Use caution if you have congestive heart failure, high blood pressure, kidney or liver disorders, or asthma (when taking aspirin).
• Prolonged use of NSAIDs may cause kidney damage. Elderly individuals and those with kidney, liver, or heart failure are at higher risk.
• Naproxen may cause drowsiness, dizziness, blurred vision, and increased blood pressure.
• Naproxen may reduce platelet aggregation and prolong bleeding time; consult a doctor if you have bleeding disorders.
• Discontinue use if serious skin reactions or rashes appear.
• Do not use without a doctor's recommendation for children under 12 years old.

Pregnancy Use

There is no evidence of harm to the fetus when used during the first or second trimester of pregnancy. However, NSAIDs inhibit prostaglandin synthesis, which may delay labor and increase the risk of neonatal death.

Breastfeeding Use

Naproxen ions have been found at about 1% concentration in the plasma of breastfeeding mothers. The decision to use this medication should consider its necessity for the mother and the health and development of the infant.

Sources: reference.medscape.com, healthline.com, drugs.com, webmd.com