Chlordiazepoxide is a benzodiazepine used to treat anxiety, alcohol withdrawal symptoms, and preoperative anxiety. Combining benzodiazepines with opioids (e.g., codeine, oxycodone, morphine) can lead to severe side effects, including respiratory depression, difficulty breathing, and even death.

Dosage and Uses of Chlordiazepoxide

- Available in 5 mg, 10 mg, and 25 mg capsules. Doses of 5–10 mg are typically used for mild to moderate anxiety or preoperative anxiety, while 25 mg is used for severe anxiety.
- It may also be prescribed for kidney disorders.
- Not recommended for children under 6 years. For children over 6 years, doses of 5 or occasionally 10 mg may be used.

Drug Interactions

Chlordiazepoxide can have severe interactions with medications such as Abametapir, Apalutamide, Benzhydrocodone, Hydrocodone, and Conivaptan. Always consult a doctor for alternatives if taking these medications.

Side Effects

Common side effects include:

• Impaired balance
• Drowsiness
• Memory issues
• Muscle weakness
• Rashes
• Decreased libido
• Menstrual irregularities
• Changes in appetite and weight

Less common side effects may include confusion, dizziness, low blood pressure, excessive salivation, sexual dysfunction, muscle cramps, tremors, tinnitus, and nasal congestion.

Precautions

Combining benzodiazepines with opioids may cause serious breathing problems, coma, or death. Limit dosage and duration as per your doctor’s advice. Misuse can lead to fatal consequences.

Physical dependence can develop, so avoid sudden discontinuation or rapid dosage reduction to prevent withdrawal symptoms, including seizures.

Contraindications

Do not use if allergic to the drug or its components.

Warnings

• Monitor closely for 3 hours after consumption.
• Exercise caution in patients with liver or kidney disorders.
• Use cautiously in respiratory issues, sleep apnea, porphyria, depression, gag reflex impairment, or suicidal tendencies.
• May impair the ability to perform hazardous tasks.
• Can cause paradoxical behaviors such as hyperactivity or aggression.
• Prolonged use may lead to physical and psychological dependence, especially in patients with a history of substance abuse or alcoholism.

Pregnancy and Breastfeeding

Due to potential harm to the fetus, use during pregnancy is recommended only when necessary and safer alternatives are unavailable. It is also not recommended during breastfeeding.

Sources: Medscape, Drugs.com